Contrast-enhanced multispectral optoacoustic tomography for the assessment of the gastrointestinal transit in patients with cystic fibrosis.

ABSTRACT: Cystic fibrosis (CF) affects the gastrointestinal tract, but assessing gastrointestinal transit usually requires invasive procedures or exposure to ionizing radiation. Contrast-enhanced multispectral optoacoustic tomography (CE-MSOT) offers a novel, non-invasive, and radiation-free approach to assess gastrointestinal function by orally administered dyes. In this clinical pilot-study five patients with cystic fibrosis and four healthy volunteers received CE-MSOT before and 6-times hourly after a standardized breakfast with Indocyanin green (ICG) as dye. The gastric antrum, terminal ileum and sigmoid colon were recorded and MSOT signals spectrally unmixed to detect ICG signals to determine the transit time. ICG excretion was confirmed by fluorescence imaging of stool samples. MSOT ICG signal

SUBMITTER: Fuchte J 

PROVIDER: S-EPMC12745951 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature