Aspartate Transaminases Are Dispensable for Pancreatic Development and Pancreatic Cancer Progression.

ABSTRACT: Pancreatic ductal adenocarcinoma (PDA) is the third leading cause of cancer-related deaths in the United States. This is due in part to the limited availability of effective treatment options for patients, highlighting a significant need for new targets and approaches. Deregulated metabolism is a hallmark feature of PDA that has gained attention as a promising inroad for therapy. The aspartate transaminases (glutamate oxaloacetate transaminases, cytosolic GOT1 and mitochondrial GOT2) have several important metabolic functions, including maintaining energy and redox balance and generating aspartate, an essential building block in protein and nucleotide biosynthesis. Previous studies of GOT proteins in preclinical tumor transplant models have yielded conflicting results regarding the require

SUBMITTER: Ugras J 

PROVIDER: S-EPMC12746018 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature