The Influence of Demographic History and Genetic Architecture on Complex Traits via Runs of Homozygosity.

ABSTRACT: Runs of homozygosity (ROH) are contiguous genomic regions where all sites are homozygous, inherited from identical haplotypes due to shared ancestry. The number and length of ROH in individuals varies based on population history and sociocultural behaviors. Although often discussed in the context of inbreeding, ROH are ubiquitous in putatively outbred human populations, and their prevalence are associated with multiple complex traits, including height and measures of lung function. Importantly, ROH have been shown to be enriched for deleterious alleles, suggesting a mechanism by which ROH prevalence can influence traits. Here we employ realistic forward-in-time population genetic simulations and a flexible quantitative model of a generic complex phenotype to explore how population history

SUBMITTER: Pan M 

PROVIDER: S-EPMC12746021 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature