Spatial and temporal effects of cortical cerebral microinfarcts on the cortical and subcortical regions in cerebral small vessel disease.

ABSTRACT:

Introduction

We assessed cortical thickness and micro-structural abnormalities associated with cortical cerebral microinfarcts (CMIs) and their temporal changes in cerebral small vessel disease (SVD).

Methods

Fifty-four participants with SVD underwent monthly magnetic resonance imaging for 10 months. Recent and old CMIs and mirrored contralateral controls were identified. Cortical and subcortical expansions around these regions were used to extract cortical thickness, R1, and neurite density index (NDI).

Results

In cortex, both recent and old CMIs showed altered NDI and R1 values only in immediate perilesional regions, likely reflecting partial-volume effects. In subcortex, recent CMIs showed no differences from controls, whereas old CMIs exhibited lower NDI along whi

SUBMITTER: Li H 

PROVIDER: S-EPMC12746041 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature