Apathy, depression, and dementia risk in older adults: A global collaborative study.

ABSTRACT:

Introduction

The role of apathy in predicting dementia risk, especially with coexisting depression, remains unclear in community-dwelling older adults.

Methods

We analyzed data from 12,646 older adults without baseline dementia across ten population-based cohorts from six continents (Cohort Studies of Memory in an International Consortium study). Apathy, depression, and dementia outcomes were assessed using harmonization protocols.

Results

Over 5.7 years of follow-up, 1160 developed dementia and 552 Alzheimer's disease (AD). Apathy prevalence was 34.1% and more than three times higher in those with depression. Apathy was not associated with dementia risk among cognitively normal or non-depressed individuals. In contrast, among individuals with depression and mild cogn

SUBMITTER: Oh DJ 

PROVIDER: S-EPMC12746046 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature