Determining optimal transit dosimetry gamma parameter values for the detection of failure modes using receiver operating curve analysis.

ABSTRACT:

Purpose

To determine the gamma criteria that maximize the sensitivity and specificity of the transit dosimetry software PerFRACTION (Sun Nuclear Corporation) under five possible failure modes in external beam radiotherapy.

Methods

We simulated five failure modes that potentially introduce large changes in the absorbed dose distribution: (1) Linac hardware incidents. In a VMAT head and neck treatment plan, erroneous plans were created, introducing known errors in the MLC aperture, the collimator angle, and the monitor units. (2) Breathing management protocol incidents. Based on a 4D-CT of a lung treatment, we created expiration and inspiration CT images. A treatment plan was created using each CT and recalculated in the alternate CT. (3) Patient identification incidents. The

SUBMITTER: Sanchez-Artunedo D 

PROVIDER: S-EPMC12746048 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature