Understanding Heterogeneity and Tolerance of Dual Candida albicans-Staphylococcus aureus Biofilms to Cold Atmospheric Plasma and Antimicrobial Combinations.

ABSTRACT: Interkingdom polymicrobial biofilms of Staphylococcus aureus and Candida albicans increase pathogenicity and complicate treatment strategies, contributing to greater morbidity and mortality. These infections are typically investigated using the C. albicans strain SC5314, despite its uncertain clinical relevance. Here, we evaluate how different C. albicans (high, intermediate, low biofilm formers) and S. aureus strains influence biofilm tolerance to both conventional antimicrobials and cold atmospheric plasma (CAP). CAP is an emerging technology that has been shown, including in our prior work, to disrupt biofilm biomass via reactive oxygen and nitrogen species, positioning it as a promising adjunct to antimicrobial therapy. We determined how strain variation influenced biofilm structure an

SUBMITTER: Duncan RM 

PROVIDER: S-EPMC12746060 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature