Parallel Selection for Longevity in Mammals and Birds.

ABSTRACT: Most studies of aging biology to date have involved the manipulation of short-lived model organisms, while the existing anti-aging mechanisms in naturally occurring long-lived vertebrates have generally remained undiscovered or understudied. The technological advances of the recent "omics revolution" have enabled comparative genomics studies, which have started to unravel genetic signatures of longevity in vertebrates. Building on prior studies and incorporating a novel approach to detecting convergent positive selection, we conducted the first genome-wide survey of positive and purifying selection among hundreds of long-lived mammals and birds, two major vertebrate taxa with notable parallels in their evolutionary history. We discovered an extensive network of shared pathways under purify

SUBMITTER: Zhang WB 

PROVIDER: S-EPMC12746067 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature