UNIQUE DEFICITS IN PLACE CODING ACROSS SUBFIELDS OF THE HIPPOCAMPUS IN A MOUSE MODEL OF TEMPORAL LOBE EPILEPSY.

ABSTRACT: Memory problems are comorbid with Temporal Lobe Epilepsy (TLE). Animal models of TLE reveal impairments in spatial firing fields of hippocampal place cells, providing a potential neural substrate for memory problems. Each subfield of the hippocampus carries out unique aspects of spatial memory, yet little is known about how individual subfields are perturbed. Here, we investigated the spatial coding properties of the three major subfields of the hippocampus. Single unit recordings were made from CA1, CA3 and the dentate gyrus (DG) of mice induced with epilepsy (N = 10, 6M/4F) using the supra-hippocampal kainate model and in control mice injected with saline (N = 6, 3M/3F). Place cell activity was measured while mice foraged in highly familiar environments to assess basic place cell propert

SUBMITTER: Boublil BL 

PROVIDER: S-EPMC12746068 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature