Target Coverage Improvement With Dose Matching in Carbon-Ion Radiation Therapy for Pancreatic Cancer.

ABSTRACT:

Purpose

Although carbon-ion radiation therapy (CIRT) creates a sharp dose distribution, inaccurate irradiation positioning may reduce the tumor dose. In pancreatic CIRT, interfractional tumor motion is a factor causing tumor dose reduction. This motion is typically accounted for in the planning target volume, and it cannot provide sufficient margin because the tumor is surrounded by the gastrointestinal tract. Online adaptive radiation therapy (ART) can solve this problem, but other problems such as equipment design and excessive time consumption remain in CIRT. The purpose of this feasibility study was to evaluate the effectiveness of dose matching (DM), which is more convenient than ART in pancreatic CIRT.

Materials and methods

On the in-room computed tomography images, se

SUBMITTER: Kusano Y 

PROVIDER: S-EPMC12746089 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature