The CCC complex directs phagosomal maturation and bactericidal activity in macrophages through PI(3)P regulation.

ABSTRACT: Phagocytosis, the process by which immune cells ingest and eliminate invading pathogens, is essential for host defense. During this process, phagosomes mature through the recruitment of several effector proteins, such as V-ATPases, proteases, and other enzymes, to effectively degrade the pathogen they contain. These maturation events are thought to be regulated by phosphoinositide transitions, which facilitate phagosome-lysosome fusion. The evolutionarily conserved COMMD/CCDC22/CCDC93 (CCC) complex regulates endosomal recycling and has been identified on phagosomes. Nevertheless, its role in phagosome maturation has not been previously demonstrated. Here, we show that the CCC complex is essential for efficient bacterial clearance by bone marrow-derived macrophages (BMDMs) and the temporal

SUBMITTER: Buck H 

PROVIDER: S-EPMC12746132 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature