Negative margins and negative HPV tests after large loop excision of the transformation zone: A nationwide historical cohort study.

ABSTRACT:

Introduction

Adequate treatment of cervical precancer, defined as negative margins and a negative HPV test post-treatment, is essential for cervical cancer prevention, as inadequate excision of cervical precancer and a positive HPV test are associated with increased risk of recurrence. Here, we aimed to describe trends in the proportion of women receiving adequate treatment in Denmark.

Material and methods

Nationwide historical cohort study including Danish women ≥18 years treated with large loop excision of the transformation zone (LLETZ) from 2013 to 2022. Using the Danish Pathology Register, we collected information on all LLETZ procedures performed due to cervical intraepithelial neoplasia grade 1 or worse (CIN1+). We calculated the proportion of negative margins and neg

SUBMITTER: Knudsen AS 

PROVIDER: S-EPMC12746177 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature