Impact of double versus single blastocyst biopsy and vitrification on clinical and neonatal outcomes in PGT cycles: A systematic review and meta-analysis of embryo retesting.

ABSTRACT:

Introduction

As PGT advances in assisted reproduction, more embryos with inconclusive results, yet potentially transferable, have emerged. Current studies reveal a disparity between the reproductive potential of retested blastocysts and the supporting evidence. This systematic review and meta-analysis compared clinical outcomes of rebiopsied and revitrified blastocysts with those biopsied and vitrified once.

Material and methods

Searches were conducted on June 26, 2024, across PubMed, EMBASE, Cochrane Library, Scopus, Web of Science, and Google Scholar, using thesaurus and free-text terms. Selection, data extraction, and risk of bias were assessed by three independent reviewers. The primary outcomes were live birth rate (LBR) and singleton birthweight; secondary outcomes wer

SUBMITTER: Vireque AA 

PROVIDER: S-EPMC12746196 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature