Metabolic gene polymorphisms and type 2 diabetes mellitus risk: A systematic review and meta-analyses.

ABSTRACT: The present systematic review and meta-analysis aimed to explore the associations between four diabetic-related genes [dipeptidyl peptidase-4 (DPP4), glucagon-like peptide-1 receptor (GLP1R), protein tyrosine phosphatase non-receptor type 1 (PTPN1) and CD36] and the risk of type 2 diabetes mellitus (T2DM) across different body weight categories. A comprehensive search for all available evidence was conducted on the associations between these four genes and T2DM, up to March 31, 2024, and 11 meta-analyses were performed on genetic polymorphisms that had been examined in >2 studies. A total of 36 studies were identified, investigating the association between the four genes of interest and T2DM risk. Notably, the 11 meta-analyses on polymorphisms in GLP1R, <

SUBMITTER: Indarto D 

PROVIDER: S-EPMC12746214 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature