Early prediction and warning of MODS following major trauma via identification of cytokine storm: A prospective cohort study.

ABSTRACT:

Purpose

Early mortality in major trauma has decreased, but MODS remains a leading cause of poor outcomes, driven by trauma-induced cytokine storms that exacerbate injuries and organ damage.

Methods

This prospective cohort study included 79 major trauma patients (ISS >15) treated in the National Center for Trauma Medicine, Peking University People's Hospital, from September 1, 2021, to July 31, 2023. Patients (1) with ISS >15 (according to AIS 2015), (2) aged 15-80 years, (3) admitted within 6 h of injury, (4) having no prior treatment before admission, were included. Exclusion criteria were (1) GCS score <9 or AIS score ≥3 for TBI, (2) confirmed infection, infectious disease, or high infection risk, (3) pregnancy, (4) severe primary diseases affecting survival, (5) recent us

SUBMITTER: Chang P 

PROVIDER: S-EPMC12746242 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature