Macrophages and TGFB signaling regulate fibrosis in the <i>Escherichia coli</i>-infected mouse prostate.

ABSTRACT: Prostate inflammation and fibrosis are linked to lower urinary tract symptoms (LUTS) in men. Uropathogenic Escherichia coli (E. coli) infection of the mouse prostate triggers a cascade of immune responses that drive inflammation and fibrosis. A recent study found that lysosome 2-positive (LYZ2+) myeloid cells (fibrocytes) are recruited in a C-C motif chemokine receptor 2 (Ccr2)-dependent manner to the E. coli-infected prostate, where they produce collagen. This study aims to identify factors that drive collagen synthesis in LYZ2+ myeloid cells during E. coli infection. We show that lymphocyte antigen 6 family member (Ly6C)^hi monocytes and their maturation products, Ly6C^hi macrophages, infiltrate the E. coli infected prostate i

SUBMITTER: Scharpf BR 

PROVIDER: S-EPMC12746299 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature