High-resolution deuterium metabolic imaging of the human brain at 9.4 T using phase-cycled balanced SSFP spectral-spatial acquisitions.

ABSTRACT:

Purpose

The aim was to improve the sensitivity and robustness against B₀ inhomogeneities of deuterium metabolic imaging (DMI) using phase-cycled balanced SSFP (bSSFP) methods at 9.4 T.

Methods

We investigated two variants of phase-cycled bSSFP acquisitions, namely uniformly weighted multi-echo and acquisition-weighted chemical shift imaging (CSI) to improve the SNR of DMI in the brain after oral [6,6'-²H₂]-glucose intake. Phase-cycling was introduced to reduce the off-resonance sensitivity of bSSFP, incurring a moderate SNR loss. Two SNR optimal methods for obtaining metabolite amplitudes from the phase-cycled bSSFP data were proposed. The SNR performance of the two bSSFP variants was compared with the SNR-optimized vendor's standard CSI. Add

SUBMITTER: Iyyappan Valsala P 

PROVIDER: S-EPMC12746357 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature