Effectiveness and safety of combining thiazides with loop diuretics vs. loop diuretics monotherapy in patients with acute decompensated heart failure: A retrospective cohort study.

ABSTRACT:

Aims

This study investigated factors associated with and outcomes of combined loop diuretics with hydrochlorothiazide (HCTZ) for acute decompensated heart failure (ADHF).

Methods

In this retrospective study, adults hospitalized for ADHF and who received intravenous loop diuretics between January 2016 and March 2023 were enrolled. Patients were categorized into two groups based on HCTZ use. Factors associated with combination therapy and clinical outcomes were examined. Effectiveness outcomes included weight change and percentage weight change, while safety outcomes focused on acute kidney injury (AKI) and worsening renal function at discharge.

Results

Among 3493 enrolled patients, 329 received combination therapy. Factors associated with combination therapy included u

SUBMITTER: Hsu CC 

PROVIDER: S-EPMC12746373 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature