Telemetric Assessment and Comparison of Regional Colonic Metabolic Activity in Ambulant Healthy Individuals Using pH and Gas-Sensing Wireless Motility Capsules.

ABSTRACT:

Background

Ingestible wireless motility capsules enable locoregional quantification of luminal pH and concentrations of hydrogen and carbon dioxide in the human colon.

Aim

To evaluate these measures in the colon of healthy adults.

Methods

Gas-sensing and pH-sensing wireless motility capsules were ingested tandemly and repeatedly over time. Measurements were analysed and compared in proximal and distal segments of the colon.

Results

In paired datasets from 37 participants, colonic pH rose from a median 6.3 (IQR 5.8-6.9) proximally to 7.0 (6.6-7.2) distally (p < 0.001). Concentrations of carbon dioxide rose in nearly all participants from 12.7 (9.1-18.6) proximally to 18.8 (11.9-28.1) %.h/h distally (p < 0.001) with a positive correlation between proximal and dis

SUBMITTER: Thwaites PA 

PROVIDER: S-EPMC12746393 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature