Recipe for Hydrogels With Tunable Relaxation and Diffusion Properties for Use as MRI Test Materials.

ABSTRACT:

Purpose

To develop and evaluate a preparation protocol (recipe) for hydrogels with specific relaxation times and ADC values to be used as tissue-like test materials for MRI experiments at 3 Tesla.

Methods

Gd-DTPA, agarose, and soy lecithin were used as modulators for T1, T2, and ADC. First, systematic measurements were performed to determine the relaxation- and diffusion-modifying properties of the single substances and combinations of them. An algorithm was developed to determine the necessary concentrations of the ingredients to achieve predetermined sets of target values (T1, T2, and ADC). To validate this approach, hydrogels mimicking the relaxation and diffusion properties of different tissues (pancreas, white matter, fibroglandular tissue, liver, prostate) were prepare

SUBMITTER: Fritz V 

PROVIDER: S-EPMC12746408 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature