Novel murine partial tracheal occlusion model with altered respiratory dynamics.

ABSTRACT: The respiratory system is integrated to optimize efficiency. Dysfunction of one element often impacts others. For example, in chronic obstructive pulmonary disease (COPD), both obstructive sleep apnea and small airways dysfunction are associated with worse emphysema. In bronchopulmonary dysplasia (BPD), cystic lung disease and tracheobronchomalacia are often comorbid. Furthermore, childhood asthma predisposes to COPD. Although mouse models have elucidated key mechanisms in respiratory disease, to date, no models have accounted for how conducting airway dysfunction impacts alveolar structure and function. We report a novel murine partial tracheal occlusion (PTO) model and a complementary esophageal pressure monitoring technique to begin answering these questions. A 50% reduction in trachea

SUBMITTER: Edwards AD 

PROVIDER: S-EPMC12746479 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature