Opioid-free anesthesia with esketamine combined with interpectoral plane block and pectoralis-serratus plane blocks in radical mastectomy: a randomized controlled trial.

ABSTRACT:

Objective

Opioid-free anesthesia (OFA) is an emerging technique that aims to reduce or eliminate intraoperative opioid use. Previous studies have shown that OFA is associated with reduced postoperative opioid consumption and fewer adverse events. This study investigated the impact of OFA on the quality of recovery (QoR) in patients undergoing radical mastectomy for breast cancer.

Methods

We enrolled 130 patients scheduled for radical mastectomy and randomly assigned them to either the opioid-free anesthesia (OFA) group or the opioid-based anesthesia (OA) group. Data from 124 patients were ultimately analyzed. The primary outcome was the Quality of Recovery-40 (QoR-40) score at 24 and 48 h postoperatively. Secondary outcomes included the Numerical Rating Scale (NRS) pain scor

SUBMITTER: Ding W 

PROVIDER: S-EPMC12746497 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature