Left atrial and ventricular remodeling in chronic mitral regurgitation.

ABSTRACT:

Objective

This study describes the structural and mechanical changes in the left atrium and left ventricle in a canine model of chronic mitral regurgitation in an attempt to identify markers linked to the onset of atrial tachyarrhythmias or left ventricle dysfunction.

Methods

Animals underwent baseline and terminal echocardiography and cardiac magnetic resonance imaging. Under echocardiographic guidance, chordae tendinae were avulsed until there was severe mitral regurgitation, defined by regurgitant jet area to left atrium area more than 70%. At terminal surgery, rapid atrial pacing was performed to test inducibility of atrial tachyarrhythmias.

Results

Twelve canines underwent mitral valve chordae avulsion and were kept alive for an average of 8.8 ± 1.3 months. Left

SUBMITTER: Yi JJ 

PROVIDER: S-EPMC12746592 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature