Combination tumors of the nervous system: A single-center analysis of a rare condition and comprehensive review of the literature.

ABSTRACT:

Background

With less than 650 published cases, combination tumors of the nervous system, that is, two locally intertwined but histologically distinct tumor entities, pose a rare constellation, its clinical relevance still being a matter of debate.

Methods

A consecutive cohort of 2530 patients operated on meningioma or hemangioblastoma between 2009 and 2021 was retrospectively screened for concomitant neoplastic disease to identify cases of combination tumors. Additionally, all available literature published between 1930 and 2021 was compiled in a comprehensive review.

Results

Our cohort comprised 144 cases of patients with concomitant neoplastic disease and among those 10 instances of combination tumors. Another instance occurred after our screening period. Benign ent

SUBMITTER: Teuber J 

PROVIDER: S-EPMC12746596 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature