New biomarkers for the diagnosis of primary central nervous system lymphoma in CSF: A multicenter retrospective cohort study.

ABSTRACT:

Background

Primary central nervous system lymphoma (PCNSL) is a rare form of non-Hodgkin lymphoma. Diagnosis usually requires a brain biopsy, which is associated with complications and delay of diagnosis. Cerebrospinal fluid (CSF) analysis can provide a diagnosis without the need for a biopsy, but only in a minority of PCNSL patients. The aim of this study is to identify new potential biomarkers in CSF for patients with clinical suspicion of PCNSL to improve the diagnostic yield of CSF analysis.

Methods

CSF samples were analyzed from a retrospective cohort that included patients with clinical suspicion of PCNSL. First-step analysis consisted of targeted multiplex biomarker analysis with use of a proximity extension assay (Olink), allowing the simultaneous analysis of relativ

SUBMITTER: van Rooij JLM 

PROVIDER: S-EPMC12746602 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature