ERO1A promotes the proliferation, migration and invasion of bladder cancer through ALOX5 mediated activation of JAK-STAT signaling pathway.

ABSTRACT:

Background

Endoplasmic reticulum oxidoreductase 1 A (ERO1A) is a protein disulfide oxidoreductase. ERO1A is involved in the progression of various tumors, but the potential mechanism of its action in bladder cancer remains unclear.

Methods

In this study, we utilized data from public databases to investigate the expression pattern of ERO1A. Through CCK-8, EdU, wound healing, and Transwell invasion assays, we evaluated the effects of ERO1A on the proliferation, migration, and invasion abilities of bladder cancer cells. We further explored the specific molecular mechanism of ERO1A. Finally, a subcutaneous tumor formation model in nude mice was established to detect the function of ERO1A in vivo.

Results

Silencing the expression of ERO1A inhibits the proliferation, migrat

SUBMITTER: Huang J 

PROVIDER: S-EPMC12746636 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature