Association between the C-reactive protein-albumin-lymphocyte (CALLY) index and osteoarthritis prevalence: a cross-sectional study of American adults based on NHANES.

ABSTRACT:

Background

Osteoarthritis (OA) is a common degenerative joint disease, and accumulating evidence suggests that metabolic and inflammatory pathways are involved in its pathogenesis. The C-reactive protein-albumin-lymphocyte (CALLY) index, an integrated biomarker incorporating serum albumin, lymphocyte counts, and C-reactive protein (CRP), has recently attracted attention as a potential indicator of systemic inflammation and nutritional status. However, its association with OA prevalence remains unclear.

Methods

We conducted a cross-sectional analysis using data from the National Health and Nutrition Examination Survey (NHANES) cycles 2001-2010 and 2015-2018. To assess external consistency, we additionally analyzed an independent hospital-based cohort (n = 1,534) and evaluated

SUBMITTER: Qi L 

PROVIDER: S-EPMC12746644 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature