CGRP restrains CD4⁺ T cell responses and allergic sensitization.

ABSTRACT:

Background

Calcitonin gene-related peptide (CGRP), a neuropeptide released by sensory neurons, plays an emerging role in immune regulation, yet its function in adaptive immunity remains poorly understood. Here, we identify the CGRP-RAMP1 pathway as a key intrinsic regulator of CD4⁺ T cell responses during allergic sensitization.

Methods

House dust mite (HDM) was used to induce allergic sensitization in mice. CGRP⁺ sensory nerve fiber distribution in mediastinal lymph nodes (medLNs) was analyzed with whole-mount imaging. RAMP1 expression on immune cells was assessed with a RAMP1-mCherry reporter by flow cytometry. TCR-seq, parabiosis, and adoptive transfer were employed to assess the biological roles of RAMP1 expression in CD4⁺ T cells. In

SUBMITTER: Li X 

PROVIDER: S-EPMC12746649 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature