Long-term liver stiffness dynamics after sustained virological response in patients with HIV/HCV co-infection and advanced fibrosis.

ABSTRACT:

Objective

This study analyses liver stiffness (LS) dynamics in people with HIV (PWH) and advanced liver fibrosis who achieved sustained virological response (SVR) and assess factors associated with LS normalization or progression, after long-term follow-up.

Design

Prospective multicenter cohort study.

Methods

This study included individuals with HIV/HCV co-infection from the Spanish GEHEP-011 cohort, fulfilling: pretreatment LS ≥9.5 kPa; sustained virological response (SVR) with direct-acting antiviral regimen; available measurement of LS at SVR. Factors associated with LS normalization (achieving ≤7.2 kPa in two consecutive measurement) and progression (increase of >20% LS at the last measurement available) were analyzed.

Results

A total of 678 patients were i

SUBMITTER: Martin-Carmona J 

PROVIDER: S-EPMC12746777 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature