Alterations in the ultrasound appearance of seminiferous tubules after gonadotropin treatment in patients with azoospermia because of hypogonadotropic hypogonadism.

ABSTRACT:

Objective

To demonstrate the relationship between ultrasound (US) changes in seminiferous tubules during gonadotropin replacement therapy and spermatogenic progression in patients with azoospermia because of hypogonadotropic hypogonadism (HH).

Design

Retrospective observational study.

Subjects

Ten patients from 2 private male infertility clinics in Japan with azoospermia because of HH received human chorionic gonadotropin (hCG) + recombinant follicle-stimulating hormone replacement (rFSH).

Exposure

Gonadotropin treatment with hCG and rFSH.

Main outcome measures

Semen analysis and US evaluation of seminiferous tubules.

Results

After the initial treatment with hCG alone, hCG and rFSH were administered by self-injection. Sperm appeared within the eja

SUBMITTER: Nariyoshi S 

PROVIDER: S-EPMC12746888 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature