Characterizing patients who underwent ovarian tissue cryopreservation at a large academic center in the United States.

ABSTRACT:

Objective

To describe characteristics and outcomes of ovarian tissue cryopreservation (OTC) patients over nearly 2 decades of institutional experience.

Design

Retrospective observational study.

Subjects

All patients who underwent OTC for any indication from January 1, 2008 to November 1, 2024.

Exposure

Ovarian tissue cryopreservation at a combined academic fertility program at the Children's Hospital of Philadelphia and the Hospital of the University of Pennsylvania.

Main outcome measures

Fertility outcomes were assessed, including oocyte and embryo vitrification, autologous ovarian tissue transplantation (OTT), pregnancies, and live births. Additionally, gonadotoxic treatment exposure and association with post-OTC outcomes, such as the development of pr

SUBMITTER: Pollie MP 

PROVIDER: S-EPMC12746891 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature