Trends and disparities in anencephaly-related early childhood mortality in the United States between 1999 and 2020: A nationwide CDC WONDER analysis.

ABSTRACT: Anencephaly is a severe neural tube defect that affects approximately 1 in every 5250 live births in the United States. This fatal congenital condition is linked to modifiable risk factors, including folic acid deficiency, maternal diabetes, and exposure to teratogenic medications such as certain anti-epileptics. Despite public health efforts to promote folic acid supplementation, disparities in mortality persist. This study aimed to evaluate national trends in anencephaly-related early childhood mortality from 1999 to 2020 using the CDC Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) database. We analyzed death certificate data from the CDC WONDER system to assess trends in anencephaly-related mortality among children from birth to 4 years of age between 1999 and 2020. Ag

SUBMITTER: Siraj HM 

PROVIDER: S-EPMC12746920 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature