Unraveling the causal link between immune cells and temporomandibular disorders: A Mendelian randomization analysis.

ABSTRACT: The host's immune inflammatory response plays a crucial role in the pathogenesis of temporomandibular disorders (TMD), involving numerous innate immune effector cells to initiate the initial inflammatory response. However, the regulation of immune function and the composition of immune cells in relation to the occurrence and development of TMD remain incompletely elucidated. The genetic causality of immune cells on TMD was studied using Mendelian randomization in a two-sample study. With the help of publicly available genetic data, we examined the causal associations between 731 immune cell signatures and TMD risk. For the causal effect analysis, an inverse variance-weighted random effect model was applied. Several sensitivity analyses were conducted by using Cochran's Q tests, funnel plot

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12746926 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature