Network pharmacology and molecular docking to explore the potential mechanism of Codonopsis pilosula delaying aging.

ABSTRACT:

Background

Codonopsis pilosula (CP), a traditional Chinese medicine, holds considerable potential in antioxidant and antiaging properties, however, the antiaging mechanism of its active components have been scarcely documented.

Methods

Network pharmacology was employed to predict the active components of CP and elucidate its underlying antiaging mechanisms. Active components of CP were retrieved from traditional Chinese medicine systems pharmacology, followed by screening targets from GeneCards. Protein-protein interaction networks were constructed using String and analyzed with Cytoscape. Pathway enrichment was done using gene ontology and Kyoto encyclopedia of genes and genomes. Finally, molecular docking of active compounds with core targets was performed using Autodock a

SUBMITTER: Liu J 

PROVIDER: S-EPMC12746927 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature