Causal relationship between palmitoylation genes mediated by immune cell phenotypes and oral cancer: A Mendelian randomized study.

ABSTRACT: Palmitoylation plays a crucial role in the development of cancer, but the causal relationship with oral cancer is still uncertain. The aim of this study was to describe the causal relationship between palmitoylation modified genes and oral cancer, while identifying intermediate factors. Genome-wide association studies of immune cells, oral cancer, and palmitoylation gene expression quantitative trait locus were derived from public databases. In this study, inverse variance weighting was used as the primary analytical method to investigate the causal relationship between exposure and outcome. In addition, this study uses Mendelian randomization (MR) Egger, simple mode, weighted median and weighted mode as supplementary analysis methods. To ensure the reliability of the findings, we further

SUBMITTER: Jiang ZH 

PROVIDER: S-EPMC12746970 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature