Causal link between coronary heart disease and lipidomics: A Mendelian randomization analysis.

ABSTRACT: The study aims to employ the 2-Sample Mendelian Randomization (MR) and Multivariable MR (MVMR) approaches to investigate the associations between specific lipid profiles and the risk of coronary heart disease (CHD). This study analyzed a comprehensive genome-wide association studies dataset comprising 179 lipidomic traits to assess the associations between various molecular subclasses of lipid traits and the risk of CHD. Causal relationships were investigated using the two-sample Mendelian randomization method, with supplementary analyses, including sensitivity analyses and MVMR, further refining the results. Heterogeneity and horizontal pleiotropy were evaluated using Cochran Q, the MR-Egger intercept test, and MR-PRESSO. Additionally, a leave-one-out sensitivity analysis was conducted to

SUBMITTER: Kang R 

PROVIDER: S-EPMC12746981 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature