Causal relationship between branched-chain amino acids and their metabolites and frailty: A two-sample Mendelian randomization study.

ABSTRACT: Increasing evidence suggests that branched-chain amino acids (BCAAs) are associated with frailty. However, whether there is a causal relationship between them remains to be seen. In addition, the metabolism of amino acids in the body is complex, and many previous studies have neglected the effects of their metabolites. The aim of this study was to investigate the relationship between BCAAs and their metabolites and indicators of frailty through Mendelian randomization (MR) methods, so as to determine the causal relationship between the 2, and to provide potential information for preventive and therapeutic strategies for frailty. A MR study was conducted using public genome-wide association studies (GWAS) data, applying inverse variance weighted as the primary method and complementary metho

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC12746989 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature