Rituximab for refractory minimal change disease: Long-term outcomes in the remission maintenance phase.

ABSTRACT: Minimal change disease (MCD) has a high recurrence rate, with refractory MCD frequently requiring long-term corticosteroid therapy or combination regimens with other immunosuppressive agents. Rituximab (RTX) has been confirmed to be an effective treatment for refractory MCD. However, its role in remission maintenance remains uncertain. This study aimed to assess RTX dosing strategies, infusion intervals, and relapse predictors during the remission maintenance phase of refractory MCD. We conducted a retrospective analysis of 14 patients with refractory MCD who had achieved complete remission with corticosteroids or conventional immunosuppressants and subsequently received RTX during the maintenance phase. The mean follow-up period was 31.1 ± 9.6 months. RTX was administered intravenously at

SUBMITTER: Tian L 

PROVIDER: S-EPMC12746990 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature