Causal genetic link between gut microbiome, metabolites, and autism spectrum disorder in a European cohort.

ABSTRACT: Recent studies have illuminated a significant relationship between the gut microbiota and the development and progression of autism spectrum disorder (ASD), mediated through the complex gut-brain axis, where metabolic pathways are crucial. Nevertheless, the exact causal link remains to be elucidated. This study aims to assess the potential causal relationship between the gut microbiota, metabolites, and ASD, utilizing Mendelian randomization methodology. The exposure variable of gut microbiota was ascertained using instrumental variables derived from a genome-wide association study that included a cohort of 18,340 individuals. The outcome variable comprised genome-wide association study data from 14,759 individuals diagnosed with ASD and 1,55,327 controls. The primary method of analysis wa

SUBMITTER: Chen C 

PROVIDER: S-EPMC12747008 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature