Association of birth weight with lung function and the mediating role of gut microbiota: A STROBE 2-step Mendelian randomization study.

ABSTRACT: Accumulating evidence has suggested that low birth weight (LBW) influences lung function deficit in adulthood. The aim of this study was to examine the relationship between LBW and adult lung function deficit and to explore the potential mediating effect of the gut microbiota in this relationship. Using summary data from genome-wide association studies, we applied 2-sample Mendelian randomization to investigate the association between birth weight and adult lung function deficit. Various MR analysis methods were used, including the inverse variance weighted, MR-Egger, weighted median, simple mode and weighted mode. Furthermore, a mediation analysis was performed to identify the potential mediating role of 412 known bacterial microbiota. This study identified significant genetic association

SUBMITTER: Cao L 

PROVIDER: S-EPMC12747014 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature