The relationship between autoimmune diseases and temporomandibular disorders: A study combined with the GEO database.

ABSTRACT: The aim of this study was to investigate the causal relationship between various autoimmune diseases (AIDs) and temporomandibular joint disorders (TMD) using Mendelian randomized (MR) analysis. Using publicly accessible statistics from genome-wide association studies (GWAS) statistics, we conducted a 2-sample MR analysis to examine the relationship between 5 prevalent AIDs and TMD, including rheumatoid arthritis (RA), multiple sclerosis (MS), ankylosing spondylitis (AS), and systemic lupus erythematosus (SLE) and psoriasis. The inverse variance weighted (IVW) was chosen as the main analysis method. The impacts of heterogeneity and pleiotropy were evaluated to validate the results. Finally, we verify the results using the bioinformatics method. Our MR analysis found RA (inverse variance wei

SUBMITTER: Gu F 

PROVIDER: S-EPMC12747028 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature