Exploring the role of palmitoylation-related genes in atrial fibrillation and analysis of immune cell infiltration.

ABSTRACT: This study aims to investigate the potential roles and mechanisms of palmitoylation-related key enzymes in atrial fibrillation (AF). AF gene expression data were obtained from the Gene Expression Omnibus database, and differentially expressed genes were screened. Thirty palmitoylation-related enzymes were selected, and differentially expressed palmitoylation-related genes (DPRGs) were further screened. Random Forest, Support Vector Machine-Recursive Feature Elimination, and Least Absolute Shrinkage and Selection Operator regression were used to screen DPRGs, and the intersection was taken as key palmitoylation-related genes (KPRGs). Their diagnostic performance was evaluated. Gene set enrichment analysis and gene set variation analysis were utilized to analyze the correlation between KPRGs

SUBMITTER: Peng S 

PROVIDER: S-EPMC12747035 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature