Role of cathepsin in mediating the effect of oral flora on myocardial infarction: A multi-omics and mediation Mendelian randomization study.

ABSTRACT: The association between oral microbiome (OM) and myocardial infarction (MI) has become a noteworthy topic in recent years, yet the role played by cathepsin in this association remains unclear. The main objective of this study was to elucidate the role of cathepsin in mediating the effect of OM on MI. The mutual causality among OM, cathepsins, and MI was analyzed using two-sample Mendelian randomization (TSMR), and the mediating role of cathepsins between OM and MI was evaluated using mediation MR analysis. Furthermore, we conducted a meta-analysis to verify the causal relationship between Cathepsin H and MI. Subsequently, we employed summary-data-based MR (SMR) method to examine the potential causal genes and proteins for Cathepsin H and acute myocardial infarction. The meta analysis resul

SUBMITTER: He Y 

PROVIDER: S-EPMC12747046 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature