Carbapenem-Resistant Enterobacteriaceae Bloodstream Infections in Neonates: Clinical Characteristics and Antimicrobial Therapy.

ABSTRACT:

Aim

To analyze the clinical characteristics, antimicrobial therapies, and outcomes of neonates with carbapenem-resistant Enterobacteriaceae (CRE) bloodstream infections.

Methods

This single-center retrospective study included 22 neonates with CRE bloodstream infections at a tertiary children's hospital in China (September 1, 2019-August 31, 2024). Data of clinical characteristics, risk factors, pathogens, carbapenemase testing, antimicrobial therapy, and outcomes were analyzed.

Results

All 22 neonates had hospital-acquired late-onset infections (males, 77.3%; preterm infants, 81.8%). Prior to onset, 72.7% of the neonates had a history of broad-spectrum antibiotic exposure. Klebsiella pneumoniae was the predominant pathogen (91.9%). Eighteen isolates underwent c

SUBMITTER: Liu Z 

PROVIDER: S-EPMC12747061 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature