Effect of a consistent reconstruction algorithm on inter-scanner reproducibility in diffusion MRI.

ABSTRACT:

Background

Diffusion MRI (dMRI) enables non-invasive characterization of brain microstructure and connectivity. However, multi-center studies face reproducibility challenges due to inter-scanner variability, which arises from differences in hardware, acquisition protocols, and image reconstruction algorithms. While prior harmonization efforts have focused on standardizing protocols and post-processing methods, the impact of using a consistent reconstruction algorithm across scanners on inter-scanner reproducibility remains unexplored.

Purpose

To evaluate the impact of consistent reconstruction algorithms on cross-vendor, inter-scanner reproducibility in diffusion MRI (dMRI) microstructure and tractography-derived measures.

Methods

Identical single-shell dMRI protocols

SUBMITTER: Liu Q 

PROVIDER: S-EPMC12747109 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature