A Rare Case of Pyoderma Gangrenosum Pointing to Waldenstrom Macroglobulinemia.

ABSTRACT:

Background

Pyoderma gangrenosum (PG) is a rare, noninfectious, truly nongangrenous, autoinflammatory condition marked by neutrophilic dermatosis. It is characterized by the rapid onset of painful, full-thickness, ulcerative skin lesions with distinctive violaceous and undermined borders. PG is commonly associated with autoimmune and hematologic disorders, namely, inflammatory bowel disease (IBD) and monoclonal gammopathy of undetermined significance (MGUS). However, it has less commonly been reported in association with lymphoplasmacytic lymphoma (LPL) and rarely with its subtype, Waldenström macroglobulinemia (WM).

Case presentation

This case unfolds the story of a 72-year-old female patient with a complex medical and primarily cutaneous oncological history, who initially d

SUBMITTER: Krishnan L 

PROVIDER: S-EPMC12747114 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature