PHD2 Deletion in CD8⁺ T Cells Worsens TAC-Induced Cardiac Inflammation, Heart Failure, and Pulmonary Remodeling.

ABSTRACT:

Background

Cardiac inflammation is a key driver of cardiac fibrosis and heart failure. Cytotoxic CD8⁺ T cells play important roles in modulating inflammatory responses, especially during infections and autoimmune diseases. HIFs (hypoxia-inducible factors) regulate CD8⁺ T cell function and cardiac remodeling. However, the role of HIF in CD8⁺ T cells during heart failure development remains unclear.

Methods

We generated CD8⁺ T cell-specific PHD2 (prolyl hydroxylase domain protein 2)-deficient mice (PHD2^CKO), in which HIF bioavailability is increased due to the loss of PHD2. PHD2^CKO and wild-type littermates were subjected to pressure overload via transverse aortic constriction. Cardiac function, inflammation, and CD8⁺ T cell responses were assessed. CD8⁺

SUBMITTER: Pan L 

PROVIDER: S-EPMC12747131 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature