Cortical response to proprioceptive stimulation in primary orthostatic tremor - a magnetoencephalography study.

ABSTRACT:

Objective

Patients with primary orthostatic tremor (OT) are affected by a strong feeling of instability. Our aim was to investigate whether cortical response to proprioceptive information is altered in OT compared with healthy control subjects (HC) using magnetoencephalography (MEG).

Methods

Fifteen OT patients and 15 HCs were examined using whole-head MEG. Proprioceptive stimulation was evoked by passive movements of the right index finger and right foot. Time-frequency responses were extracted in the frequency range of 8-30 Hz. The MEG sensor with the highest amplitude change time-locked to the proprioceptive stimulus was used to calculate the amplitude of event-related desynchronization (ERD) and subsequent event-related re-synchronization (ERS).

Results

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SUBMITTER: Edholm KA 

PROVIDER: S-EPMC12747180 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature