Ascorbate elastomer-coated ePTFE grafts inhibit neointimal hyperplasia and enhance vascular healing.

ABSTRACT: Severe peripheral arterial disease (PAD) is often treated with surgical bypass grafting using autologous vein. When veins are unavailable, small-diameter expanded polytetrafluoroethylene (ePTFE) grafts are used but are associated with long-term poor performance. To address this, we developed poly(1,8-octanediol-co-citrate-co-ascorbate) (POCA) elastomer coatings for small-diameter ePTFE grafts that indirectly release nitric oxide via decomposition of circulating S-nitrosothiols (RSNO). Graft in vivo efficacy was assessed using a guinea pig aortic interposition model to evaluate neointimal formation. After 4 weeks, POCA-Grafts demonstrated significantly less occlusion compared to uncoated ePTFE grafts (16.8 % versus 29.7 %, p < 0.0005) and POC (poly(1,8-octanediol-co-cit

SUBMITTER: Yu L 

PROVIDER: S-EPMC12747211 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature