Proximal Tubule-Specific Genetic Deficiency of PPARα Worsens Systemic Lipid and Glucose Metabolism During Fasting.

ABSTRACT: The proximal tubule (PT) of the kidney is a highly metabolic organ that regulates systemic homeostasis through ketogenesis and gluconeogenesis. Peroxisome proliferator-activated receptor alpha (PPARα), a nuclear receptor controlling fatty acid oxidation (FAO) and homeostasis, is expressed in the PT and is activated by fasting. Although the activation of systemic PPARα is essential for renal and systemic energy metabolism, the role of PPARα in PT has not been established. In this study, kidney PT-specific PPARα knockout mice (Ppara^∆KPT) were generated, and the metabolic changes caused by 48 h of fasting were compared between Ppara^∆KPT mice and controls. In Ppara^∆KPT mice, renal FAO and ketogenesis were severely impaired, leading to lipid accumulation in the

SUBMITTER: Aomura D 

PROVIDER: S-EPMC12747219 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature